Package: HDXBoxeR 0.0.2
HDXBoxeR: Analysis of Hydrogen-Deuterium Exchange Mass-Spectrometry Data
A protocol that facilitates the processing and analysis of Hydrogen-Deuterium Exchange Mass Spectrometry data using p-value statistics and Critical Interval analysis. It provides a pipeline for analyzing data from 'HDXExaminer' (Sierra Analytics, Trajan Scientific), automating matching and comparison of protein states through Welch's T-test and the Critical Interval statistical framework. Additionally, it simplifies data export, generates 'PyMol' scripts, and ensures calculations meet publication standards. 'HDXBoxeR' assists in various aspects of hydrogen-deuterium exchange data analysis, including reprocessing data, calculating parameters, identifying significant peptides, generating plots, and facilitating comparison between protein states. For details check papers by Hageman and Weis (2019) <doi:10.1021/acs.analchem.9b01325> and Masson et al. (2019) <doi:10.1038/s41592-019-0459-y>. 'HDXBoxeR' citation: Janowska et al. (2024) <doi:10.1093/bioinformatics/btae479>.
Authors:
HDXBoxeR_0.0.2.tar.gz
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HDXBoxeR.pdf |HDXBoxeR.html✨
HDXBoxeR/json (API)
# Install 'HDXBoxeR' in R: |
install.packages('HDXBoxeR', repos = c('https://mkajano.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/mkajano/hdxboxer/issues
Last updated 3 months agofrom:63fdd47db2. Checks:OK: 7. Indexed: yes.
Target | Result | Date |
---|---|---|
Doc / Vignettes | OK | Oct 18 2024 |
R-4.5-win | OK | Oct 18 2024 |
R-4.5-linux | OK | Oct 18 2024 |
R-4.4-win | OK | Oct 18 2024 |
R-4.4-mac | OK | Oct 18 2024 |
R-4.3-win | OK | Oct 18 2024 |
R-4.3-mac | OK | Oct 18 2024 |
Exports:all_summaryarg_dfarg_UN_FDarguments_call1arguments_call2arguments_call3av_tcav_tpave_timepointaverage_timecoursebackHX_calculationsboxplot_tpCI_2ptsCI_singleCI_tcCI_tpcolor_ranges_Blue_Red_heat_mapcolor_ranges_Spectralcoverage_residuedeuteration_woods_timecoursedeuteration_woods_timepointsdif_avedif_tpdif_tp_procduplicate_setsextreme_input_gapextreme_input_undeutgeneral_infogetCoords1heat_map_tcheat_map_tpheat_map_tp_maxuptakeheat_map_tp_maxuptake_procheat_map_tp_proclab_diflab_dif_proclab_vollegend_heat_maplegend_heat_map_tclegend_heat_map_timecourselegend_heat_map_tplegend_heat_map_tp_proclegend_nm_bottomlegend_raw_avelegend_raw_ave_proclegend_raw_ave_tclegend_sig_peptideslegend_states_PerD_bottomlegend_tc_bottomnb_exch_deutnm_statesoutput_FDoutput_FD_procoutput_prepoutput_tcoutput_tpoutput_UDoutput_UD_procpallette_legendpallette_llpeptide_pv_tppeptide_pv_tp_procpl_gen_ch2pl_gen_uptakeplot_heat_map_max_uptake_tpplot_heat_map_max_uptake_tp_procplot_heat_map_tcplot_heat_map_tpplot_heat_map_tp_procplot_peptide_sig_tpplot_peptide_sig_tp_procplots_av_tcourseplots_av_tpplots_av_tp_procplots_diff_tpplots_diff_tp_procplots_vol_tppparppar_bottom_legendppar_widerpparLMprep_timecourse_plot_aveprep_timecourse_plot_sdpv_timecoursepv_timepointpymol_script_average_residuepymol_script_significant_peptidepymol_script_significant_peptide_procpymol_script_significant_residuepymol_script_significant_residue_procpymol_strqpcr.cbind.naranges_functionranges_function_tcrbind_nareset_parrobot_2states_indexesrobot_indexesrobot_indexes_dfrobot_plot_Allsd_timecoursesd_timecourse_procsd_timepointselect_indicessignificant_peptide_uptakesummary_sd_CIuptake_plotsverbose_timecourse_outputverbose_timepoint_outputvol_tpwoods_CI_plot
Dependencies:clicpp11dplyrfansigenericsgluelifecyclemagrittrpillarpkgconfigpurrrR6RColorBrewerrlangstringistringrtibbletidyrtidyselectutf8vctrswithrwrapr